Tarzana is surrounded by Reseda to the north, Woodland Hills to the west, Encino to the east, and the Santa Monica Mountains to the south. Major thoroughfares include Reseda Boulevard, Tampa Avenue, Wilbur Avenue, Burbank Boulevard and the commercial backbone of the south San Fernando Valley, Ventura Boulevard.
Most of Tarzana's inhabitants live in the foothills of the Santa Monica Mountains south of Ventura Blvd. North of Ventura, there is a uniquely designed area meant to emulate a more rural setting called Melody Acres. Tarzana contains two country clubs (with golf courses) nestled in the Santa Monica Mountains: El Caballero Country Club and Braemar Country Club. At the remote southern end of Reseda Blvd., there are a number of luxurious gated communities, including Mulholland Park, Silverhawk Ridge, Monte Verde and Braemar Estates.
The area now known as Tarzana was originally part of the San Fernando Mission, which was established in 1797 by Spanish settlers and missionaries, who eventually displaced the indigenous population. Later on the area was seized by Mexico and then sometime afterwards, the United States, at which point the area came to be part of a sequential order of large cattle ranches owned by the wealthy and powerful local elites. Beginning in the 1870s, the area was purchased by investors who transformed it into a large-scale wheat farm operation.
In 1915 Edgar Rice Burroughs, best known as the author of the Tarzan stories, purchased Otis˙ land, upon which he built a large home, and renamed the property Tarzana Ranch. Burroughs subdivided and sold the land for residential development, while the neighboring small farms were also converted to residential areas. In 1927, local residents renamed the town Tarzana in honor of Burroughs and his famous literary character.